With the start of the college football season around the corner, betting odds for more late-season matchups are being released.

For the Oregon Ducks' biggest games against opponents such as the Ohio State Buckeyes and the USC Trojans, DraftKings Sportsbook released odds in the early summer months. With the fall quickly approaching and depth charts beginning to take place, betting odds for more of Oregon's games have been released, including the season finale against Washington.

Odds for the Oregon vs. Nebraska matchup were also released, but the focus here remains one of the Ducks' most bitter rivals. The Ducks face Ohio State and USC on the road in 2026, the Huskies will be traveling to Eugene to play Oregon, and Washington is expected to come to town as a double-digit underdog.

Oregon vs. Washington Betting Odds

According to early odds from DraftKings Sportsbook, Oregon coach Dan Lanning and the Ducks are favored by 15.5 points over Washington, and the over/under is set at 54.5 points. Obviously the betting spread is expected to change as the season progresses and teams deal with depth issues as well as unexpected breakout pieces.

In the 2025 edition of the Oregon vs. Washington rivalry, Ducks receiver Malik Benson stepped up with injuries to receivers like Dakorien Moore, Gary Bryant Jr., and Evan Stewart limiting the number of targets available for Oregon quarterback Dante Moore.

Washington quarterback Demond Williams returns after throwing for 3,065 yards, 25 touchdowns, and 8 interceptions while completing 69.5 percent of his passes. He's also a threat with his legs, finishing with the second-most rushing yards on the Huskies a season ago. However, he struggled against the Ducks in 2025, completing 15 of 30 passes for 129 yards, 2 touchdowns, and 2 interceptions. Oregon also held Williams to 27 yards on 10 carries.

Williams is still expected to lead Washington towards the top of the Big Ten this season, and the Huskies could be one of the conference's biggest spoilers. Washington coach Jedd Fisch and the Huskies have Big Ten matchups with USC, Iowa, Penn State, Indiana, and Oregon, and the Huskies are expected to be underdogs against the Trojans, Hoosiers, and the Ducks.

Oregon Ducks' Potential Playoff Résumé

The rivalry game is far away, but the Ducks can feel somewhat comfortable as two-touchdown favorites. One potential question is if Washington will be ranked at that point in the regular season?

Oregon might not need a boost to its résumé at the end of the year, but picking up a ranked win a rivalry game never hurts. The Ducks are expected to be favored against every opponent except Ohio State, but anything more than one loss could put Lanning and company on the bubble of making the College Football Playoff.

The expectation around the Ducks, especially with the return of Moore, is to not only make the CFP but to compete in the 12-team field. As a result, taking care of business in regular season games, especially rivalry ones, becomes paramount for Lanning and company.

The Ducks coach has often said that winning games leaves little doubt for the CFP committee, and the game against Washington could be Oregon's last step before the program gets another chance at the postseason.

Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

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